Tylenol (acetaminophen) provides real but modest relief for arthritis pain, and the honest truth is that most patients find it less effective than anti-inflammatory alternatives. A large Cochrane review of osteoarthritis trials found that acetaminophen reduced pain by only about 5% more than a placebo on a 100-point scale, an improvement so small that its clinical meaningfulness is debatable. TYLENOL® 8 Hour Arthritis Pain Caplets with 650 mg acetaminophen is fast, effective relief from minor arthritis & joint pain. Tylenol Arthritis Pain package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Acetaminophen is the main active ingredient in Tylenol products for pain, arthritis, headache, and fever. Explore TYLENOL® arthritis products containing the active ingredient acetaminophen to help alleviate minor arthritis and joint pain symptoms. Tylenol and Tylenol Arthritis both contain acetaminophen, but differ in dose and release speed. Here’s what that means for pain relief and safety. Tylenol (acetaminophen) is an over-the-counter pain reliever and fever reducer used for headache, muscle aches, backache, arthritis, toothache, sore throat, menstrual cramps, colds, and flu. Discover effective arthritis pain relief with Tylenol's trusted acetaminophen formulas. Available in multiple sizes. The pain is constant throughout the day. Taking Tylenol Arthritis regularly (on a schedule) provides steadier relief. Because Tylenol Arthritis is an Extended Release formula, it is designed to last up to 8 hours. Taking it at set intervals keeps a steady level of medication in your system, preventing the pain from spiking. Learn about Tylenol products for muscle, joint, and arthritis pain, including extended-release tablets, combination pain relievers, topical creams and patches, safe usage, and side effects.